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O. Häusler (1) , Ph. Lefèvre (1)
(1) Roquette Frères, 62080 Lestrem, France.
Introduction
Partially pregelatinized corn starches are free-flowing and self-disintegrating powders. Their physico-chemical properties are well adapted to the use as filler-disintegrant in two-piece hard gelatin capsules. A new product, LYCATAB® C has been recently developed for this application. The following study has been done to compare the performance of LYCATAB® C with the similar excipient Starch 1500® in its recommended application as filler for two-piece hard gelatin capsules.
Conclusion
- This study demonstrates that both partially pregelatinized corn starches LYCATAB® C and Starch 1500® are useful filler-disintegrants for hard gelatin capsules.
- Several differences, both in the powder physical properties and in the disintegration time of capsules were observed. They could be explained as result of dissimilar particle structures caused by two different production technologies.
- The more compact structure of LYCATAB® C seems to be important for getting optimal results in capsules production.
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