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E. schwarz(1), V. Fichtner(1), B. Irlinger(1), and O. Haeusler (2)
(1) Meggle GmbH, 83512 Wasserburg, Germany
(2) Roquette Frères, Lestrem (F).
Introduction
Lactose is a very common used filler in pharmaceutical solid dosage forms. A combination with cellulose to improve compressibility or with starch to modify disintegration time is also widely used. For such formulations lubrication is requested. The various lubrications have a diverse influence on tablet characteristics.
Our investigations focus on the effect of these lubricants on the disintegration time of the co-processed excipient vs. the physical blend. Other important characteristics like tablet hardness and ejection force are also reported.
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