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(1) Institute of Pharmaceutical Technology, University of Bonn
(2) Meggle GmbH &Co. KG, 83512 Wasserburg, Germany
Introduction
Often granulation is the first step in the production of tablets. Since the instrumentation of the roller compactor improved and the process can be sufficient controlled, it became a standard technique. Former publication described the decrease of tensile strength after second compaction [1].
Lactose-monohydrate and starch are very often used in pharmaceutical formulations for
solid dosage forms. In our study we focused on the influence of the particle size
distribution of milled lactose-monohydrate qualities as well as lactose/starch
combinations.
[1] S.Erling: Trockengranulation: Entwicklung einer Basisrezeptur für die Walzenkompaktierung, Diplomarbeit University Bonn, Germany
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