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Ashish A. Joshi, PhD - Xavier Duriez, PhD
Reproduced courtesy of Pharmaceutical Technology
Tablets and capsules are preferred drug delivery vehicles because they can be precisely dosed, easily manufactured and be packaged on a large scale, and can contribute to good patient compliance. Over the years, significant advances in the manufacturing processes of oral solid dosage forms have occurred, including the transition from tablet preparation by wet granulation to direct compression. The development of various added functionality excipients (AFEs), which are used to achieve formulations with desired end-effects, is equally important.
The majority of excipients used in the manufacture of solid oral dosage forms have existed for the past two to three decades, many of them continue to be used today for large-scale tablet and capsule manufacturing.
Authors: Ashish A. Joshi, PhD, is Project Coordinator (Pharma/Nutra) at Roquette America Inc, Keokuk, IA 52632.
Xavier Duriez, PhD, is Pharma Business Manager at Roquette Frères, Lestrem, France.
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