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Ashish A. Joshi, P. Lefevre and X. Duriez
AAPS, 2005
Orally Disintegrating Tablets (ODTs) are fast gaining popularity as a novel oral drug delivery system. When placed in mouth, these tablets rapidly absorb the small quantity of available saliva and quickly disperse in about 10-45 sec.
ODTs demonstrate unique advantages by addressing patient compliance issues with pediatric, geriatric and uncooperative patients unable to swallow tablets. They also allow administration of medication without any need for water.
To-date a variety of ODTs with their own claim of advantages have been developed using technologies ranging from as simple as wet granulation or direct compression to as complex lyophilization.
An ideal combinationof excipients for ODTs should provide the following:
Allow satisfactory drug loading and exhibit good moisture stability
Mask bitter taste of drugs and offer an overall pleasant mouth feel
Yield sufficiently robust tablets upon direct compression
Enable rapid dispersion in the mouth without leaving any residue
No single excipient can fulfill the requirements of all ODT formulations. The study will assess the suitability of excipients and superdisintegrants for developing an ODT platform using conventional and non-conventional tests. This data may ultimately help in selection of the best possible combination of excipient and superdisintegrant for developing an optimal ODT formulation.
For further information contact
pharma.business.unit@roquette.com
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