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>> October 2001 - Influence of Magnesium Stearate on the Compaction Behavior and Tablet Characteristics of Co-Spray Dried Compounds versus Physical Blends

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Rudolf Schröder1,Olaf Häusler2, Eugen Schwarz3 and Klaus-Jürgen Steffens1
AAPS, 2001

  • 1 - Universität Bonn, Pharmazeutische Technologie, 53121 Bonn, Germany
  • 2 - Roquette Frères
  • 3 - Meggle GmbH, 83512 Wasserburg, Germany

The study evaluates the influence of Mg-Stearate on the compaction and tablet behavior of co-spray dried compounds versus physical blends based on lactose and starch or lactose and MCC.

The change in physical properties by co-spray drying is reported for excipients. Also the influence of Mg-Stearate on the disintegration and dissolution.

The disintegration time depending on the concentration of Mg-Stearate is also featured.

For further information contact pharma.business.unit@roquette.com
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Roquette Pharma is a global manufacturer and supplier of pharmaceutical excipients, actives and cosmetics ingredients, providing also services and formulation assistance. Roquette's pharma specialities are ideally suited for pharmaceutical and drug formulations : oral dosage forms such as tablets, capsules, paste products including tooth paste, injectable solutions, clinical nutrition and nutraceutical products, liquid and confectionery forms.