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>> April 2002 - Co-processed Compound Based on Lactose and Starch Compared to Physical Mixtures :Tablet Formation and Disintegration at Different Maxium Relative Densities

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Karsten Hauschild (1) , Olaf Häusler (2) , Eugen Schwarz (3) and Katharina Maria Picker
(1) Martin-Luther-University Halle-Wittenberg, Department of Pharmacy, Institute of Pharmaceutical Technology and Biopharmacy, Halle/Saale, Germany. e-mail: picker@pharmazie.uni-halle.de
(2) Roquette Freres, Lestrem, France.
(3) Meggle GmbH, Wasserburg, Germany.

Aim of this study

  • Direct compression is a major formulation process in Pharmaceutical Technology. StarLac® is a new direct compression excipient, produced by spray-drying of α - lactose-monohydrate and maize starch.
  • The aim of this study is to study the tablet formation of a compound based on lactose and starch (85:15 w/w) compared to the pure substances and graded physical mixtures. Pressure-time-profiles, pressure-porosity profiles and compactibility-plots help to evaluate the tableting properties.
  • Second aim is to study in detail the disintegration and drug release from tablets of StarLac® compared to those of the physical mixture and this especially at higher maximum relative densities.
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Roquette Pharma is a global manufacturer and supplier of pharmaceutical excipients, actives and cosmetics ingredients, providing also services and formulation assistance. Roquette's pharma specialities are ideally suited for pharmaceutical and drug formulations : oral dosage forms such as tablets, capsules, paste products including tooth paste, injectable solutions, clinical nutrition and nutraceutical products, liquid and confectionery forms.