|
St. Korittky and K.-J. Steffens
Institute of Pharmaceutical Technology, Bonn University, Gerhard-Domagk-Str. 3, D-53121 Bonn, Germany
Summary
The main purpose of this study was to find an excipient that tolerates dual compression without a decrease of tensile strength. Especially StarLac® 25/75 is almost non-sensitive to dual compression. Further types of StaLac® with different ratios of lactose monohydrate and maize starch have yet to be tested.
Introduction
Often granulation is the first step in the tablet manufacturing process. By now, roller compaction became a standard dry granulation technique. Former publications depict a phenomenon. When compressed twice (1st: roller compaction, 2nd: tabletting), the tablets show a significantly lower tensile strength than tablets with similar composition which are directly compressed. The decrease of tensile
strength was found for all excipients in former experiments, only the level of that effect differs.
The purpose of this study is to determine the suitability of different excipients for roller compaction, especially to find an excipient that tolerates dual compression without a decrease of tensile strength.
|
