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K. Hauschild and K.M. Picker
Martin-Luther-University Halle-Wittenberg, Department of Pharmacy, Institute of Pharmaceutical Technology and Biopharmacy, 06120 Halle/Saale, Germany
Aim of this study
Direct compression is a major formulation process in Pharmaceutical Technology. StarLac® is a new direct compression excipient, produced by spray-drying of α - lactose-monohydrate and maize starch. Powder properties like densities and particle size distribution are useful to characterize the flowability of materials. Pressure-time-profiles, pressure-porosity- profiles and compactibility plots help to evaluate the tableting properties.
Aim of this study is to characterize both the pure substances and the physical mixtures of spray-dried lactose and maize starch in comparison to the new direct compression excipient StarLac®.
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